Gene information
Official symbol LIMK1
Official full name LIM domain kinase 1
Gene type protein-coding gene
Chromosome7q11.23
Alias symbolLIMK
Gene familyLIM domain containing; PDZ domain containing; LIMK/TESK kinase family
Resources
Entrez Gene 3984
HGNC HGNC:6613
Ensembl ENSG00000106683
Vega OTTHUMG00000023448
UCSC uc003uaa.3
GO terms: 51 records
GO Description Category LogP Number of genes Detail
GO:0001558 regulation of cell growth GO Biological Processes -19.1123936 65 More
GO:0004672 protein kinase activity GO Molecular Functions -2.03527804 36 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0006468 protein phosphorylation GO Biological Processes -5.36604576 56 More
GO:0007264 small GTPase mediated signal transduction GO Biological Processes -2.76738893 22 More
GO:0007265 Ras protein signal transduction GO Biological Processes -1.87357952 15 More
GO:0007266 Rho protein signal transduction GO Biological Processes -1.86130079 7 More
GO:0008361 regulation of cell size GO Biological Processes -4.6524989 21 More
GO:0010638 positive regulation of organelle organization GO Biological Processes -6.49207636 47 More
GO:0010720 positive regulation of cell development GO Biological Processes -17.713649 52 More
GO:0010975 regulation of neuron projection development GO Biological Processes -5.89330331 41 More
GO:0030027 lamellipodium GO Cellular Components -1.61995196 15 More
GO:0030029 actin filament-based process GO Biological Processes -9.62516039 61 More
GO:0030036 actin cytoskeleton organization GO Biological Processes -5.67075265 47 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030307 positive regulation of cell growth GO Biological Processes -13.7154299 34 More
GO:0031072 heat shock protein binding GO Molecular Functions -1.83303292 11 More
GO:0031252 cell leading edge GO Cellular Components -1.97716247 28 More
GO:0031344 regulation of cell projection organization GO Biological Processes -8.91314416 62 More
GO:0031346 positive regulation of cell projection organization GO Biological Processes -6.78114948 37 More
GO:0031397 negative regulation of protein ubiquitination GO Biological Processes -2.56497893 10 More
GO:0031400 negative regulation of protein modification process GO Biological Processes -17.0986645 70 More
GO:0032231 regulation of actin filament bundle assembly GO Biological Processes -4.42971140 15 More
GO:0032535 regulation of cellular component size GO Biological Processes -4.60941253 33 More
GO:0032956 regulation of actin cytoskeleton organization GO Biological Processes -4.25470878 32 More
GO:0032970 regulation of actin filament-based process GO Biological Processes -7.72273150 43 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045773 positive regulation of axon extension GO Biological Processes -2.96833359 7 More
GO:0045927 positive regulation of growth GO Biological Processes -20.3035639 52 More
GO:0048638 regulation of developmental growth GO Biological Processes -23.5012496 63 More
GO:0048639 positive regulation of developmental growth GO Biological Processes -14.4198804 35 More
GO:0050767 regulation of neurogenesis GO Biological Processes -15.7439029 55 More
GO:0050769 positive regulation of neurogenesis GO Biological Processes -12.1167088 37 More
GO:0050770 regulation of axonogenesis GO Biological Processes -3.56457741 17 More
GO:0050772 positive regulation of axonogenesis GO Biological Processes -1.81127841 8 More
GO:0051348 negative regulation of transferase activity GO Biological Processes -13.2006110 43 More
GO:0051492 regulation of stress fiber assembly GO Biological Processes -3.91249954 13 More
GO:0051493 regulation of cytoskeleton organization GO Biological Processes -3.52271067 40 More
GO:0051495 positive regulation of cytoskeleton organization GO Biological Processes -3.67944181 20 More
GO:0051960 regulation of nervous system development GO Biological Processes -17.2202851 64 More
GO:0051962 positive regulation of nervous system development GO Biological Processes -13.2580156 43 More
GO:0060284 regulation of cell development GO Biological Processes -22.9455891 78 More
GO:0061387 regulation of extent of cell growth GO Biological Processes -3.21598264 13 More
GO:0110020 regulation of actomyosin structure organization GO Biological Processes -4.68299748 15 More
GO:0110053 regulation of actin filament organization GO Biological Processes -3.93783734 26 More
GO:0120035 regulation of plasma membrane bounded cell projection organization GO Biological Processes -8.54789693 60 More
GO:1902903 regulation of supramolecular fiber organization GO Biological Processes -5.63791156 37 More
GO:1902905 positive regulation of supramolecular fiber organization GO Biological Processes -5.32876142 22 More
GO:1903321 negative regulation of protein modification by small protein conjugation or removal GO Biological Processes -2.63408119 11 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04360 Axon guidance KEGG Pathway -1.69032736 7 More
Drug-Gene interaction
view
Related drugs: 22 records
Drug name Interaction type Source PMID View
alisertib DTC view
bms-345541 DTC view
cenisertib DTC view
chembl1997335 DTC view
chembl546797 DTC view
chir-99021 DTC view
dactolisib DTC view
dasatinib DTC view
dovitinib DTC view
gefitinib DTC view
go-6976 DTC view
gw843682x DTC view
ilorasertib DTC view
jnj-7706621 DTC view
kenpaullone DTC view
lauroguadine DTC view
pazopanib DTC view
rg-1530 DTC view
sb-220025 DTC view
sorafenib DTC view
tae-684 DTC view
tozasertib DTC view
Related study: 1 record
Molecular factor Omics type Application Objective MI type Reference
Chr7:74084359 hypermethylation epigenomics ischemic cardiac events[prognosis (bad)] myocardial infarction Thunders M et al. Epigenetics. 2019
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